Article

Melatonin Biosynthesis, Receptors, and the Microbiota–Tryptophan–Melatonin Axis: A Shared Dysbiosis Signature across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories --- (<em>Microbiota–Melatonin Axis in Disease and Cognition</em>)

2025-12-04

Abstract excerpt

<h4>Background: </h4> Melatonin, an indolic neuromodulator with oncostatic and anti-inflammatory properties, is produced at extrapineal sites—most notably in the gut. Its canonical actions are mediated by high-affinity GPCRs (MT1/MT2) and by the melatonin-binding enzyme NQO2 (historically “MT3”). A growing body of work highlights a bidirectional interaction between the gut microbiota and host melatonin. <h4>Method...

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Literature Corpus work: ef3c6bce-08c6-54c6-9c6e-09e20152144e
DOI: 10.20944/preprints202512.0427.v1

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Melatonin Biosynthesis, Receptors, and the Microbiota–Tryptophan–Melatonin Axis: A Shared Dysbiosis Signature across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories --- (<em>Microbiota–Melatonin Axis in Disease and Cognition</em>)DOI 10.20944/preprints202512.0427.v1Read

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