Article

Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease

2025-05-01

Abstract excerpt

We previously identified microbial shifts prior to the onset of motor and neurological symptoms within a mouse model of the fatal neurodegenerative disease Machado-Joseph disease (MJD). Here, we aimed to explore possible mechanisms contributing to these changes within the microbiome-gut-brain axis, and whether it preceded or followed central neurodegeneration. Here, we report that pre-symptomatic male MJD mice pre...

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Identifiers and source

Literature Corpus work: cdba9174-1d0b-52da-8db5-f76edc17bb88
DOI: 10.1101/2025.04.30.651362

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