Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melatonin system integrity shapes gut-brain interaction in schizophrenia-derived microbiota transplant phenotype in mice.

Life sciences - 15 Oct 2026

Barzon Benedetta, Shkodra Atea, D'Incalci Michele, Sapienza Jacopo, Paribello Pasquale, Nasini Sofia, Dall'Acqua Stefano, Bertazzo Antonella, Pitsikas Nikolaos, De Gregorio Danilo, Valtorta Flavia, Manchia Mirko, Squassina Alessio, Fadda Paola, Cavallaro Roberto, Pisanu Claudia, Bosia Marta, Comai Stefano

Abstract excerpt

AIMS: This study investigates whether the melatonin (MLT) system modulates the behavioral, neurophysiological and neurochemical effects of fecal microbiota transplantation (FMT) from individuals with schizophrenia (SCZ), highlighting the role of the tryptophan (Trp) to MLT and kynurenine (Kyn) pathways. MATERIALS AND METHODS: FMT was performed using fecal samples from individuals with SCZ, characterized by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Gastrointestinal Microbiome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kynurenine

Share to Melatonin

Share to Mice, Inbred C3H

Share to Mice, Inbred C57BL

Share to Schizophrenia

Share to Tryptophan

Source

Identifiers

PMID: 42580395
DOI: 10.1016/j.lfs.2026.124633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melatonin system integrity shapes gut-brain interaction in schizophrenia-derived microbiota transplant phenotype in mice.PMID 42580395Read ↗

Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in miceSemantic proximity Read ↗

Melatonin Biosynthesis, Receptors, and the Microbiota–Tryptophan–Melatonin Axis: A Shared Dysbiosis Signature across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories --- (<em>Microbiota–Melatonin Axis in Disease and Cognition</em>)Semantic proximity Read ↗

Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in miceSemantic proximity Read ↗

The fecal microbiota transplantation from drug-naïve schizophrenia patients distinctively changes gut microbiome and metabolic profiles in male and female miceSemantic proximity Read ↗

Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping reviewSemantic proximity Read ↗

Metagenome-wide association of gut microbiome features for schizophreniaSemantic proximity Read ↗

Tryptophan metabolism and the gut-brain axis: focus on specific gut microbial generaSemantic proximity Read ↗

Donor Microbiota Metabolic Capacity Determines Engraftment Dynamics and Modulates Gut–Brain Signaling in Recipient MiceSemantic proximity Read ↗

Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot studySemantic proximity Read ↗

Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and DiseaseSemantic proximity Read ↗

The Kynurenine Pathway as a Convergent Hub Linking Toll-Like Receptor Signaling, Environmental Exposures, and Gut–Brain Axis Dysfunction in Neurodegenerative DiseasesSemantic proximity Read ↗

Gut microbiota and sleep: Interaction mechanisms and therapeutic prospectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.