Article

Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis

2024-08-23

Abstract excerpt

<h4>Background & Aims</h4> Ulcerative colitis (UC) is associated with epithelial metabolic derangements which exacerbate gut inflammation. Patient-derived organoids recapitulate complexities of the parent tissue in health and disease; however, whether colon organoids (colonoids) model metabolic impairments in the pediatric UC epithelium is unclear. This study determined the functional metabolic differences in the...

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Literature Corpus work: 1c23bad2-03e0-5c31-b1af-a3b804013a6e
DOI: 10.1101/2024.08.22.609271

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