Article

Reduced intestinal GLP-1 <sup>+</sup> cell numbers are associated with an inflammation-related epithelial metabolic signature

2025-03-10

Abstract excerpt

<h4>Background & Aims</h4> Enteroendocrine cells (EECs) are known for their role in digestion and metabolism, yet their role in intestinal inflammation remains unclear. In inflammatory bowel diseases (IBD), a contribution of EECs to pathogenesis is indicated by autoantibodies affecting EEC function and general disease symptoms like insulin resistance and altered intestinal motility. Particularly, the L cell-deriv...

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Literature Corpus work: 83c3cde7-6510-5706-84bb-f8670dbb08fa
DOI: 10.1101/2025.03.05.641577

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