Article

p57Kip2 regulates embryonic haematopoietic stem cell numbers by controlling the size of the sympathoadrenal progenitor pool

2021-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Haematopoietic stem cells (HSCs) are of major clinical importance, and finding methods for their in vitro generation is a prime research focus. We demonstrate that the cell cycle inhibitor p57Kip2/Cdkn1c limits HSC numbers by restricting the size of the sympathetic nervous system (SNS) and the amount of HSC-supportive catecholamines secreted by these cells, specifically in the aorta-gonads-meso...

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Literature Corpus work: 1bee5daa-f09e-5586-b251-980edc37cca8
DOI: 10.1101/2021.09.13.459835

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