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Article

Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis

27 Jan 2022

Abstract excerpt

The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving haematopoietic stem cell quiescence and maintenance under proliferative stress remain largely unknown. Here we found that cholinergic signals preserve haematopoietic stem cell quiescence in bone-associated (endosteal) bone marrow...

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PMID: 35087060
DOI: 10.1038/s41467-022-28175-1

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