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Article

Prime editing: Mechanism insight and recent applications in plants.

Plant biotechnology journal - 1 Jan 2024

Vu Tien V, Nguyen Ngan Thi, Kim Jihae, Hong Jong Chan, Kim Jae-Yean

Abstract excerpt

Prime editing (PE) technology utilizes an extended prime editing guide RNA (pegRNA) to direct a fusion peptide consisting of nCas9 (H840) and reverse transcriptase (RT) to a specific location in the genome. This enables the installation of base changes at the targeted site using the extended portion of the pegRNA through RT activity. The resulting product of the RT reaction forms a 3' flap, which can be...

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Identifiers

PMID: 37794706
DOI: 10.1111/pbi.14188
PMCID: PMC10754014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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