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Article

Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy.

Circulation. Heart failure - 1 Nov 2021

Eijgenraam Tim R, Boogerd Cornelis J, Stege Nienke M, Oliveira Nunes Teixeira Vivian, Dokter Martin M, Schmidt Lukas E, Yin Xiaoke, Theofilatos Konstantinos, Mayr Manuel, van der Meer Peter, van Rooij Eva, van der Velden Jolanda, Silljé Herman H W, de Boer Rudolf A

Abstract excerpt

BACKGROUND: The p.(Arg14del) pathogenic variant (R14del) of the PLN (phospholamban) gene is a prevalent cause of cardiomyopathy with heart failure. The exact underlying pathophysiology is unknown, and a suitable therapy is unavailable. We aim to identify molecular perturbations underlying this cardiomyopathy in a clinically relevant PLN-R14del mouse model. METHODS: We investigated the progression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34587756
DOI: 10.1161/CIRCHEARTFAILURE.121.008532
PMCID: PMC8589082

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Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy.PMID 34587756Read ↗

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