Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

21 Mar 2019

Abstract excerpt

Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for treating genetic diseases. However, responses triggered by programmable nucleases in HSPCs are poorly characterized and may negatively impact HSPC engraftment and long-term repopulation capacity. Here, we induced either one or several DNA double-stranded breaks (DSBs) with optimized zinc-finger and CRISPR/Cas9 nucleases and...

Source

Identifiers

PMID: 30905619
DOI: 10.1016/j.stem.2019.02.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage ResponsePMID 30905619Read ↗

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential HurdlesSemantic proximity Read ↗

p38 MAPK fuels proliferation stress and DNA damage impairing the functionality of genetically engineered hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cellsSemantic proximity Read ↗

Clinical hematopoietic stem cell-based gene therapySemantic proximity Read ↗

MEGA dPCR reveals chromosomal aberrations, NHEJ precise repair, recurrent nuclease cleavage and DSB half-lifeSemantic proximity Read ↗

Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem CellsSemantic proximity Read ↗

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1Semantic proximity Read ↗

Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Homology-Directed-Repair-Based Genome Editing in HSPCs for the Treatment of Inborn Errors of Immunity and Blood DisordersSemantic proximity Read ↗

Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapySemantic proximity Read ↗

Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cellsSemantic proximity Read ↗

A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.