Article

Is the CHEK2 Gene Able to Offer Platinum Sensitivity Despite Low Variant Allele Frequency? A Case Report and Review in Literature

2026-05-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Molecular profiling, particularly concerning homologous recombination repair (HRR) genes, is increasingly crucial in managing endocrine therapy (ET) resistance in hormone receptor-positive (HR+) breast cancer. While CHEK2 is a recognized moderate-penetrance susceptibility gene, its predictive value for therapeutic responses to specific systemic agents, especi...

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Literature Corpus work: 1bc7ce5e-ee3f-5679-bb4a-c74dc47485f0
DOI: 10.21203/rs.3.rs-9525276/v1

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