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Article

Sensitivity to systemic therapy for metastatic breast cancer in CHEK2 1100delC mutation carriers.

Journal of cancer research and clinical oncology - 1 Oct 2015

Kriege Mieke, Jager Agnes, Hollestelle Antoinette, Berns Els M J J, Blom Jannet, Meijer-van Gelder Marion E, Sieuwerts Anieta M, van den Ouweland Ans, Collée J Margriet, Kroep Judith R, Martens John W M, Hooning Maartje J, Seynaeve Caroline

Abstract excerpt

PURPOSE: The role of CHEK2 in DNA repair by homologous recombination suggests that CHEK2-associated breast cancer (BC) patients might be more sensitive to chemotherapy inducing double-strand DNA breaks, but results hereon are lacking. We compared the sensitivity to first-line chemotherapy and endocrine therapy between CHEK2 1100delC and non-CHEK2 metastatic breast cancer (MBC) patients. METHODS: Sixty-two CHEK2...

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Identifiers

PMID: 25958056
DOI: 10.1007/s00432-015-1981-7
PMCID: PMC4543421

Genes

CHEK2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Sensitivity to systemic therapy for metastatic breast cancer in CHEK2 1100delC mutation carriers.PMID 25958056Read ↗

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Survival and contralateral breast cancer in CHEK2 1100delC breast cancer patients: impact of adjuvant chemotherapy.Semantic proximity Read ↗

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survivalSemantic proximity Read ↗

Breast cancer sensitivity to neoadjuvant therapy in BRCA1 and CHEK2 mutation carriers and non-carriers.Semantic proximity Read ↗

Breast Cancer Survival and Tumor Characteristics in Premenopausal Women Carrying the <i>CHEK2*1100delC</i> Germline MutationSemantic proximity Read ↗

Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Breast cancer in patients carrying a germ-line CHEK2 mutation: Outcome after breast conserving surgery and adjuvant radiotherapy.Semantic proximity Read ↗

Is the CHEK2 Gene Able to Offer Platinum Sensitivity Despite Low Variant Allele Frequency? A Case Report and Review in LiteratureSemantic proximity Read ↗

CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.Semantic proximity Read ↗

Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant.Semantic proximity Read ↗

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Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.Semantic proximity Read ↗

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