Article

Genomic ascertainment of<i>CHEK2</i>-related cancer predisposition

2024-08-08

Abstract excerpt

<h4>Purpose</h4> There is clear evidence that deleterious germline variants in CHEK2 increases risk for breast and prostate cancers; there is limited or conflicting evidence for other cancers. Genomic ascertainment was used to quantify cancer risk in CHEK2 germline pathogenic variant heterozygotes. <h4>Patients and Methods</h4> Germline CHEK2 variants were extracted from two exome-sequenced biobanks linked to the...

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Literature Corpus work: d0b319b1-acb9-5a8d-8ebb-13a52a5d569c
DOI: 10.1101/2024.08.07.24311613

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