Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.

Current hematologic malignancy reports - 1 Aug 2022

Stubbins Ryan J, Korotev Sophia, Godley Lucy A

Abstract excerpt

PURPOSE OF REVIEW: An intact DNA damage response is crucial to preventing cancer development, including in myeloid and lymphoid malignancies. Deficiencies in the homologous recombination (HR) pathway can lead to defective DNA damage responses, and this can occur through inherited germline mutations in HR pathway genes, such as CHEK2 and ATM. We now understand that germline mutations can be identified frequently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Checkpoint Kinase 2

Share to Genetic Predisposition to Disease

Share to Germ Cells

Share to Hematologic Neoplasms

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Source

Identifiers

PMID: 35674998
DOI: 10.1007/s11899-022-00663-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.PMID 35674998Read ↗

Impact of Germline DNA Repair Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Development.Semantic proximity Read ↗

Impact of Germline CHEK2 Pathogenic Variants on the Risk of Acute Myeloid Leukemia and Myelodysplastic Syndrome.Semantic proximity Read ↗

Germline CHEK2 mutations in patients with myeloid neoplasms.Semantic proximity Read ↗

Predisposition to hematopoietic malignancies by deleterious germline CHEK2 variants.Semantic proximity Read ↗

CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate.Semantic proximity Read ↗

Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.Semantic proximity Read ↗

Clinical interpretation of pathogenic ATM and CHEK2 variants on multigene panel tests: navigating moderate risk.Semantic proximity Read ↗

Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American populationSemantic proximity Read ↗

Clinicopathologic and genetic analysis of invasive breast carcinomas in women with germline CHEK2 variants.Semantic proximity Read ↗

Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia.Semantic proximity Read ↗

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors.Semantic proximity Read ↗

The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.