Article

Do Amyloid Trajectories Reach a Physiologic Ceiling? Evidence from Iterative Approximation and Simulation

2026-04-21

Abstract excerpt

Qualitative models of Alzheimer’s pathology often posit that amyloid accumulation follows a sigmoid curve, indicating that the rate of deposition wanes over time. Longitudinal PET data now allow us to investigate amyloid accumulation trajectories with greater detail and over longer follow-up periods. We combine inferences from simulated amyloid trajectories, empirical PET data from the Alzheimer’s Disease Neuroima...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b96933e-704d-590a-b8fd-ba1a2e5840c2
DOI: 10.64898/2026.04.14.26350359

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Do Amyloid Trajectories Reach a Physiologic Ceiling? Evidence from Iterative Approximation and SimulationDOI 10.64898/2026.04.14.26350359Read

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer’s Disease using PET and Plasma BiomarkersSemantic proximity Read

Learning a Continuous Progression Trajectory of Amyloid in Alzheimer diseaseSemantic proximity Read

Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer DiseaseSemantic proximity Read

Quantifying natural amyloid plaque accumulation in the continuum of Alzheimer’s disease using ADNISemantic proximity Read

Computational Risk Stratification of Preclinical Alzheimer’s in Younger AdultsSemantic proximity Read

Trajectories of amyloid beta accumulation - Unveiling the relationship with APOE genotype and cognitive decline.Semantic proximity Read

A data-driven Alzheimer’s disease progression simulator for retrospective validation and prospective Phase III power designSemantic proximity Read

Design-induced artifacts when “disease clocks” are plugged into second-stage analyses of symptom onsetSemantic proximity Read

Mapping U.S. POINTER Cognitive-Slope Gains Onto Predicted Clinical Progression: An External-Cohort Translation Analysis With Exploratory Economic ThresholdsSemantic proximity Read

Simulating the outcome of amyloid treatments in Alzheimer’s disease from imaging and clinical dataSemantic proximity Read

Metrics for Distinguishing Biological Versus Interventional Change in AI ModelsSemantic proximity Read

CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in PDSemantic proximity Read