Article

Mapping U.S. POINTER Cognitive-Slope Gains Onto Predicted Clinical Progression: An External-Cohort Translation Analysis With Exploratory Economic Thresholds

2026-05-20

Abstract excerpt

<h4>Background</h4> U.S. POINTER reported a modest structured-versus-self-guided difference in the annual rate of global cognitive change. However, the clinical and economic implications of this incremental standardized cognitive-slope benefit for delaying progression from cognitively normal status to mild cognitive impairment or dementia remain uncertain. <h4>Objectives</h4> To translate the U.S. POINTER cognit...

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Literature Corpus work: 2a05a728-0eff-5f10-80ae-68bf78bfb493
DOI: 10.64898/2026.05.17.26353395

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