Article

Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease

2026-07-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Disease progression modeling (DPM) or “amyloid time” is increasingly used to stage Alzheimer disease (AD). DPM performance depends on within-individual heterogeneity in rates of pathological accumulation as well as test-retest reliability of the biomarker. The relative contributions of these variabilities have not been systematically assessed. This would be particularly relev...

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Literature Corpus work: 3652d921-d515-5a2c-9a2f-1955d4bedc73
DOI: 10.64898/2026.07.08.737258

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