Article

Design-induced artifacts when “disease clocks” are plugged into second-stage analyses of symptom onset

2026-04-01

Abstract excerpt

<h4>Background and Aims</h4> Plasma phosphorylated tau 217 (p-tau217), including %p-tau217, has emerged as a robust biomarker of Alzheimer’s disease (AD) pathology, with increasing interest in its longitudinal behavior. In “Predicting onset of symptomatic Alzheimer’s disease with plasma p-tau217 clocks,” Petersen et al. applied disease clock models, Sampled Iterative Local Approximation (SILA) and Temporal Integr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2afa08d-6e28-57be-a391-ace21abce381
DOI: 10.64898/2026.03.26.26349230

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Design-induced artifacts when “disease clocks” are plugged into second-stage analyses of symptom onsetDOI 10.64898/2026.03.26.26349230Read

The countdown paradox: time-varying analysis of biomarker-clock age and symptom onsetSemantic proximity Read

Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer DiseaseSemantic proximity Read

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer’s Disease using PET and Plasma BiomarkersSemantic proximity Read

Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom OnsetSemantic proximity Read

Multi-method investigation of factors influencing amyloid onset and impairment in three cohortsSemantic proximity Read

Plasma p-tau217 predicts cognitive impairments up to ten years before onset in normal older adultsSemantic proximity Read

Predicting Preclinical Cognitive Decline Using Plasma P-tau217 and <i>APOE</i> Genotype in 8,582 Individuals From Different Ethnic GroupsSemantic proximity Read

Aligning personalized biomarker trajectories onto a common time axis: a connectome-based ODE model for Tau–Amyloid beta dynamicsSemantic proximity Read

Data-driven models of dominantly-inherited Alzheimer’s disease progressionSemantic proximity Read

A multi-modal phase plane method for constructing multivariate disease trajectoriesSemantic proximity Read

Genetic Associations with Temporal Modeling of Alzheimer’s Disease Progression Supports a Novel Paradigm for Disease RiskSemantic proximity Read

Data-driven models of dominantly-inherited Alzheimer’s disease progressionSemantic proximity Read