Article

Integrative analysis reveals a macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer

2024-06-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Salivary gland cancers (SGC) are rare and heterogeneous malignant tumors. Advanced SGC lack established treatment options and show poor response to immunotherapy. Here, an integrative multi-omics analysis in a large cohort of advanced SGC revealed insights into the tumor immune microenvironment (TIM) and distinct mechanisms of immune evasion. <h4>Methods</h4> A total of 104 pa...

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Literature Corpus work: 1b966ae8-22dd-513c-ad32-67491874ba8e
DOI: 10.1101/2024.06.11.24308538

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