Article

Reversible Downregulation of HLA Class I in Adenoid Cystic Carcinoma

2024-09-07

Abstract excerpt

<h4>Purpose</h4> Adenoid cystic carcinoma (ACC), a rare and lethal cancer, has shown low response rates to systemic therapies, such as cytotoxic chemotherapy and immune-checkpoint inhibitors (ICIs). Despite numerous clinical trials, some employing aggressive ICI combinations, no effective treatments for patients with recurrent or metastatic adenoid cystic carcinoma have emerged, and ACC mortality rates remain sta...

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Literature Corpus work: 8ab9c289-84c8-578a-9580-182ab142b352
DOI: 10.1101/2024.09.03.610529

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