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Article

Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancer.

Asia-Pacific journal of clinical oncology - 1 Dec 2024

Nagatani Yoshiaki, Kiyota Naomi, Imamura Yoshinori, Koyama Taiji, Funakoshi Yohei, Komatsu Masato, Itoh Tomoo, Teshima Masanori, Nibu Ken-Ichi, Sakai Kazuko, Nishio Kazuto, Shimomura Manami, Nakatsura Tetsuya, Ikarashi Daiki, Nakayama Takayuki, Kitano Shigehisa, Minami Hironobu

Abstract excerpt

AIM: Although immune checkpoint inhibitors (ICPi) for salivary gland cancer (SGC) have been investigated in clinical trials, details of the tumor immune microenvironment (TIME) remain unclear. This research aimed to elucidate the TIME of SGC and its relationship with tumor mutation burden (TMB) and to explore the rationale for the applicability of ICPi. MATERIALS AND METHODS: We selected five pathological types,...

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PMID: 39233454
DOI: 10.1111/ajco.14108

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