Back to search

Article

Dual Transcriptional Drivers of Immune Suppression in SACC: <i>NOTCH1</i> for Cellular and <i>MYB</i> for Humoral Immunity

2025-11-17

Abstract excerpt

As a classic immune-“cold” tumor, salivary adenoid cystic carcinoma (SACC) represents a significant clinical challenge. Through sequencing analyses, we identify profound systemic immune dysregulation in SACC, characterized by suppressed hematopoiesis, T-cell exhaustion, compensatory myelopoiesis, and an expanded immature B-cell compartment. While lung metastases exhibit a relatively immune-engaged microenvironment...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b2b12417-3a9c-59e9-8a4d-d3e291fbea3d
DOI
10.1101/2025.11.17.688163
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Dual Transcriptional Drivers of Immune Suppression in SACC: <i>NOTCH1</i> for Cellular and <i>MYB</i> for Humoral ImmunityDOI 10.1101/2025.11.17.688163
Integrative analysis reveals a macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancerSemantic proximity
Gene-Expression Programs in Salivary Gland Adenoid Cystic Carcinoma Analyzed Using Single-Cell and Spatial TranscriptomicsSemantic proximity
The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype.Semantic proximity
Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancer.Semantic proximity
Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathwaySemantic proximity
Increased retinoic acid signalling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathwaySemantic proximity
Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancerSemantic proximity
Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II.Semantic proximity
Adenoid cystic carcinoma: emerging role of translocations and gene fusionsSemantic proximity
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.Semantic proximity
Reversible Downregulation of HLA Class I in Adenoid Cystic CarcinomaSemantic proximity
Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomesSemantic proximity
Select a neighboring publication to make it the new centre.