Article

Biophysical Simulation Enables Multi-Scale Segmentation and Atlas Mapping for Top-Down Spatial Omics of the Nervous System

2024-08-03

Abstract excerpt

Spatial omics (SO) has produced high-definition mapping of subcellular molecules (like transcripts or proteins) within tissue samples. Mapping transcripts to anatomical regions requires segmentation, but even segmenting nuclei remains challenging for tissues like nerve cross sections, let alone for larger regions such as within the spinal cord. Neural networks could address this but need extensive human annotation...

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Literature Corpus work: 1b939cb5-3fa4-53ee-8a04-5872c37138bf
DOI: 10.1101/2024.08.02.605366

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