Article

Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data

2024-03-04

Abstract excerpt

Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at subcellular resolution within intact tissue sections and cell lines. However, necessary image segmentation to single cells is challenging and error prone, easily confounding the interpretation of cellular phenotypes and cell clusters. To address these limitations, we pre...

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Literature Corpus work: 67165390-c73b-5043-b167-755ce3c2f625
DOI: 10.1101/2024.02.29.582827

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