Article

Confocal Raman Microscopy-Guided Optimization of Early Otic Differentiation from Human Pluripotent Stem Cells

2026-06-25

Abstract excerpt

Generation of otic progenitors from pluripotent stem cells requires precise timed regulation of signalling pathways, including bone morphogenetic protein 4 (BMP4). Because endogenous levels of BMP4 varie between cell lines, the optimal concentration of exogenous BMP4 must be determined individually to achieve efficient otic differentiation. Three different human induced pluripotent stem cell lines (hiPSCs) underwe...

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Literature Corpus work: 1b8984f5-aee0-5052-bc1b-4102bcd463a2
DOI: 10.64898/2026.06.24.734338

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