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Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells

7 Nov 2024

Abstract excerpt

The production of mature functioning thyroid follicular cells (TFCs) from human induced pluripotent stem cells (iPSCs) is critical for potential novel therapeutic approaches to post-surgical and congenital hypothyroidism. To accomplish this, we developed a novel human iPSC line that expresses fluorophores targeted to the NKX2-1 and PAX8 loci, allowing for the identification and purification of cells destined to...

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PMID: 39515316
DOI: 10.1016/j.stemcr.2024.10.004

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