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Article

Hepatocyte-Specific Fads1 Overexpression Attenuates Western Diet-Induced Metabolic Phenotypes in a Rat Model.

International journal of molecular sciences - 29 Apr 2024

Ghooray Dushan T, Xu Manman, Shi Hongxue, McClain Craig J, Song Ming

Abstract excerpt

Fatty acid desaturase 1 (FADS1) is a rate-limiting enzyme in long-chain polyunsaturated fatty acid (LCPUFA) synthesis. Reduced activity of FADS1 was observed in metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of this study was to determine whether adeno-associated virus serotype 8 (AAV8) mediated hepatocyte-specific overexpression of Fads1 (AAV8-Fads1) attenuates western diet-induced...

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Identifiers

PMID: 38732052
DOI: 10.3390/ijms25094836
PMCID: PMC11084797

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