Article

Modeling Laryngeal Dystonia through Spectral Analyses of Vocalizations in a Dystonia Mouse Model

2025-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Laryngeal dystonia is a task-specific, focal dystonia that disrupts vocal-motor control and significantly alters quality of life through impaired communication. Despite its early onset in many hereditary dystonias, effective treatments remain limited, in part due to the lack of a preclinical model that captures its circuit-level pathophysiology. Our experiment evaluates ultrasonic vocalizations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77407ec8-b8d1-53c8-bc3e-e378536fca33
DOI: 10.1101/2025.07.07.663183

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling Laryngeal Dystonia through Spectral Analyses of Vocalizations in a Dystonia Mouse ModelDOI 10.1101/2025.07.07.663183Read

Cerebellar Dysfunction as a Source of Dystonic Phenotypes in MiceSemantic proximity Read

Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in miceSemantic proximity Read

Recent advances in understanding and managing dystoniaSemantic proximity Read

Cerebellar deep brain stimulation as a dual-function therapeutic for restoring movement and sleep in dystonic miceSemantic proximity Read

Quantification of Behavioral Deficits in Developing Mice With Dystonic BehaviorsSemantic proximity Read

Phenomenology, genetics, and CNS network abnormalities in laryngeal dystonia: A 30-year experience.Semantic proximity Read

Ultrasonic vocalizations in Shank mouse models for autism spectrum disorders: detailed spectrographic analyses and developmental profiles.Semantic proximity Read

Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulationSemantic proximity Read

Loss of cGMP-dependent protein kinase II alters ultrasonic vocalizations in mice, a model for speech impairment in human microdeletion 4q21 syndromeSemantic proximity Read

Circuitry dynamics of the cerebellum inform differential therapeutic responses and patient stratification in essential tremorSemantic proximity Read

Postinspiratory complex acts as a gating mechanism regulating swallow-breathing coordination and other laryngeal behaviorsSemantic proximity Read

Ndufs4 inactivation in glutamatergic neurons reveals swallow-breathing discoordination in a mouse model of Leigh SyndromeSemantic proximity Read