Article
Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity.
Developmental biology - 1 Apr 2017
Lee Myungsin, Yoon Jiyeon, Song Hobeom, Lee Bumwhee, Lam Duc Tri, Yoon Jaeseung, Baek Kwanghee, Clevers Hans, Jeong Yongsu
Abstract excerpt
The thalamus acts as a central integrator for processing and relaying sensory and motor information to and from the cerebral cortex, and the habenula plays pivotal roles in emotive decision making by modulating dopaminergic and serotonergic circuits. These neural compartments are derived from a common developmental progenitor domain, called prosomere 2, in the caudal forebrain. Thalamic and habenular neurons...
Topics
- Animals
- Axon Guidance
- Axons
- Biomarkers
- Body Patterning
- Diencephalon
- Habenula
- Homeodomain Proteins
- Mice
- Mitosis
- Mutation
- Nerve Net
- Neurons
- Protein Binding