Article

A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development

2022-10-24

Abstract excerpt

<title>Abstract</title> <p>Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type 2 innate lymphoid cells (ILC2) that is evolutionarily optimized for epithelial remodeling in response to helminth infection. We demonstrate that tuft cell-derived interleuk...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f935b16e-98ab-51cc-bf79-f971a22a89e8
DOI: 10.21203/rs.3.rs-2180571/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor developmentDOI 10.21203/rs.3.rs-2180571/v1Read

Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in miceSemantic proximity Read

Circulating inflammatory ILC2s as a biomarker of gastric cancer progressionSemantic proximity Read

An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis.Semantic proximity Read

IL13 Acts Directly on Gastric Epithelial Cells to Promote Metaplasia Development During Chronic GastritisSemantic proximity Read

Dynamic changes of the immune microenvironment in the development of gastric cancer caused by inflammationSemantic proximity Read

Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokinesSemantic proximity Read

Single-cell RNA sequencing revealed the T cell heterogeneity and exhaustion subsets of Helicobacter pylori-induced gastritis - cancer transformationSemantic proximity Read

Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pyloriSemantic proximity Read

ILC2 Activation by Protozoan Commensal MicrobesSemantic proximity Read

BATF acts as an essential regulator of IL-25–responsive migratory ILC2 cell fate and functionSemantic proximity Read

scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectorySemantic proximity Read

Mutational Signatures and Clonal Hematopoiesis in Intestinal Metaplasia across Countries with Varying Stomach Cancer Incidence.Semantic proximity Read