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Integrative miRNA–mRNA Network and Molecular Dynamics-Based Identification of Therapeutic Candidates for Paroxysmal Nocturnal Hemoglobinuria

2025-12-19

Abstract excerpt

<h4>Background: </h4> Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disease, characterized primarily by intravascular hemolysis, thrombosis, and bone marrow failure. Complement inhibitors are commonly used in clinical treatment, showing limited efficacy, thus highlighting the urgent need to identify new therapeutic targets and explore alternative treatment strategies to provide th...

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Literature Corpus work
1b478921-bc51-5ac4-b0a7-6f24283785e3
DOI
10.20944/preprints202512.1665.v1
Open publication

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