Article

Long Non-Coding RNA FAM157C Contributed to Clonal Proliferation in Paroxysmal Nocturnal Hemoglobinuria

2021-01-18

Abstract excerpt

<title>Abstract</title> <p>Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disease of hematopoietic stem cells. However, the mechanism of proliferative advantage of PNH clone is unclear. Long noncoding RNAs (LncRNAs) have a wide range of biological functions, including regulation of gene expression, cell differentiation, and proliferation, while its role in PNH remains unclear. <h4>Methods:...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac37c1cd-aaaa-57ca-bcfa-dc193108dcd9
DOI: 10.21203/rs.3.rs-147083/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Long Non-Coding RNA FAM157C Contributed to Clonal Proliferation in Paroxysmal Nocturnal HemoglobinuriaDOI 10.21203/rs.3.rs-147083/v1Read

Identifying Genes Associated With Proliferation, Immunity and Thrombosis in Paroxysmal Nocturnal Haemoglobinuria.Semantic proximity Read

Single-cell transcriptomic analysis identifies an immune erythroid in paroxysmal nocturnal hemoglobinuriaSemantic proximity Read

Dysregulation of the miRNA-30a-5p/B4GALT5 axis leads to cell proliferation and is associated with M1 Macrophage Polarization in PNHSemantic proximity Read

[Advances in research for pathogenesis of paroxysmal nocturnal hemoglobinuria].Semantic proximity Read

Recent insights into the pathophysiology of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read

Imputing causality and clonal dynamics from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read

Heterogeneity in the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH) syndromes and expansion mechanism of a PNH clone.Semantic proximity Read

Clinical features and prognostic factors of Asian patients with paroxysmal nocturnal hemoglobinuria: results from a single center in China.Semantic proximity Read

Identification of acquired PIGA mutations and additional variants by next-generation sequencing in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read

Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal HemoglobinuriaSemantic proximity Read

Nationwide real-world cohort of paroxysmal nocturnal hemoglobinuria in ChileSemantic proximity Read

Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read