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Article

Identifying Genes Associated With Proliferation, Immunity and Thrombosis in Paroxysmal Nocturnal Haemoglobinuria.

Journal of cellular and molecular medicine - 1 Dec 2024

Du Yali, Wang David, Hu Qinglin, Lai Zhizhen, Yang Chen, He Huiwen, Wang Shuqing, Zhang Huijuan, Chen Peng, Li Zepeng, Chen Miao, Han Bing

Abstract excerpt

PIGA mutation cannot fully explain the proliferative advantage of abnormal clones and thrombosis tendency in paroxysmal nocturnal haemoglobinuria (PNH), and additional genes may play a role, justifying further investigation. CD59+ and CD59- peripheral blood mononuclear cells from six PNH patients were sorted and subjected to whole-exon sequencing (WES) and whole-transcriptome sequencing respectively. Six age- and...

Topics

Humans
Hemoglobinuria, Paroxysmal
Male
Female
Thrombosis
Cell Proliferation
Adult
Middle Aged
CD59 Antigens
Leukocytes, Mononuclear
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity

Exome Sequencing

Membrane Proteins

Case-Control Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 39671267
DOI: 10.1111/jcmm.70295
PMCID: PMC11640899

Genes

CD59
PIGA
FLT1
NRP1
SELP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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