Article

An integrative proteomics approach identifies tyrosine kinase KIT as a novel therapeutic target for SPINK1-positive prostate cancer

2023-07-25

Abstract excerpt

Elevated Serine Peptidase Inhibitor, Kazal type 1 (SPINK1) levels in ∼10-25% of prostate cancer (PCa) patients associate with aggressive phenotype, for which there are limited treatment choices and dismal clinical outcomes. Using an integrative proteomics approach involving label-free phosphoproteome and proteome profiling, we delineated the downstream signaling pathways involved in SPINK1-mediated tumorigenesis i...

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Literature Corpus work: 1b144f7c-1b1c-5b31-b445-ce83d459a556
DOI: 10.1101/2023.07.24.550265

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