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Article

Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer

26 Dec 2018

Abstract excerpt

Abstract Purpose: Serine peptidase inhibitor, Kazal type-1 (SPINK1) overexpression defines the second most recurrent and aggressive prostate cancer subtype. However, the underlying molecular mechanism and pathobiology of SPINK1 in prostate cancer remains largely unknown. Experimental Design: miRNA prediction tools were employed to examine the SPINK1-3′UTR for miRNA binding. Luciferase reporter assays were...

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PMID: 30587549
DOI: 10.1158/1078-0432.ccr-18-3230

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