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Article

Functional Roles of SPINK1 in Cancers.

International journal of molecular sciences - 7 Apr 2021

Lin Tsung-Chieh

Abstract excerpt

Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease inhibitor of trypsin in the pancreas. However, emerging evidence shows its function in promoting cancer progression in various types of cancer. SPINK1 modulated tumor malignancies and induced the activation of the downstream signaling of epidermal growth factor receptor (EGFR) in cancer cells, due to the structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33916984
DOI: 10.3390/ijms22083814
PMCID: PMC8067593

Genes

SPINK1
EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Functional Roles of SPINK1 in Cancers.PMID 33916984Read ↗

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