Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrence

10 Jul 2013

Abstract excerpt

BACKGROUND: The serine peptidase inhibitor, Kazal type 1 (SPINK1) has been suggested to define an aggressive molecular subtype of ERG-fusion negative prostate cancer. It was the aim of this study to further study the clinical relevance of SPINK1 expression and its relationship with other key genomic alterations of prostate cancer. METHODS: A tissue microarray containing more than 10,000 prostate cancers with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research
Share to Urinary Bladder and Prostate Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23843146
DOI: 10.1002/pros.22707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrencePMID 23843146Read ↗

Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration‐resistant prostate cancerSemantic proximity Read ↗

A high-density tissue microarray from patients with clinically localized prostate cancer reveals ERG and TATI exclusivity in tumor cellsSemantic proximity Read ↗

An integrative proteomics approach identifies tyrosine kinase KIT as a novel therapeutic target for SPINK1-positive prostate cancerSemantic proximity Read ↗

Reduced KLK2 expression is a strong and independent predictor of poor prognosis in ERG-negative prostate cancer.Semantic proximity Read ↗

Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci.Semantic proximity Read ↗

Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes.Semantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.Semantic proximity Read ↗

Integration of <i>ERG</i> gene mapping and gene‐expression profiling identifies distinct categories of human prostate cancerSemantic proximity Read ↗

Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancerSemantic proximity Read ↗

Pseudogene associated recurrent gene fusion in prostate cancerSemantic proximity Read ↗

Loss of PTEN Is Associated with Aggressive Behavior in ERG-Positive Prostate CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.