Article

Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer

2018-07-24

Abstract excerpt

<h4>Purpose</h4> Serine Peptidase Inhibitor, Kazal type-1 (SPINK1) overexpression defines the second most recurrent and aggressive prostate cancer (PCa) subtype. However, the underlying molecular mechanism and pathobiology of SPINK1 in PCa remains largely unknown. <h4>Experimental Design</h4> MicroRNA-prediction tools were employed to examine the SPINK1- 3’UTR for miRNAs binding. Luciferase reporter assays were...

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Literature Corpus work: b315e886-0264-54c5-b57e-f32e57204d30
DOI: 10.1101/376277

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