Article

Activation of the adhesion GPCR GPR133 (ADGRD1) by antibodies targeting the N-terminus

2021-09-14

Abstract excerpt

We recently demonstrated that GPR133 (ADGRD1), an adhesion G protein-coupled receptor (aGPCR) whose canonical signaling raises cytosolic cAMP, is necessary for growth of glioblastoma (GBM) and is de novo expressed in GBM relative to normal brain tissue. We showed that dissociation of autoproteolytically generated N-terminal and C-terminal fragments (NTF and CTF) of GPR133 at the plasma membrane promotes receptor...

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Literature Corpus work: 1aeb6eb4-2930-5fe9-aa56-51438eda6e8b
DOI: 10.1101/2021.09.13.460139

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