Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2‐positive breast cancer

10 Jun 2021

Abstract excerpt

While G protein-coupled receptors (GPCRs) are known to be excellent drug targets, the second largest family of adhesion-GPCRs is less explored for their role in health and disease. ADGRF1 (GPR110) is an adhesion-GPCR and has an important function in neurodevelopment and cancer. Despite serving as a poor predictor of survival, ADGRF1's coupling to G proteins and downstream pathways remain unknown in cancer. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HER2/EGFR in Cancer Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34110646
DOI: 10.1096/fj.202100070r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2‐positive breast cancerPMID 34110646Read ↗

The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancersSemantic proximity Read ↗

Pathophysiological impact of the adhesion G protein-coupled receptor familySemantic proximity Read ↗

The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer—Comprehensive Study Based on In Silico AnalysisSemantic proximity Read ↗

A Bioinformatic Investigation into the Role of ITGB1 in Cancer Prognosis and Therapeutic ResistanceSemantic proximity Read ↗

Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India.Semantic proximity Read ↗

Adhesion G protein-coupled receptor G2 accelerates the proliferation of cancer cells by promoting the formation of CDK4/CCND1Semantic proximity Read ↗

GPRC5A: An Emerging Biomarker in Human CancerSemantic proximity Read ↗

GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in GlioblastomaSemantic proximity Read ↗

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancerSemantic proximity Read ↗

The G Protein-Coupled Estrogen Receptor (GPER) Expression Correlates with Pro-Metastatic Pathways in ER-Negative Breast Cancer: A Bioinformatics AnalysisSemantic proximity Read ↗

Beclin 1 regulates growth factor receptor signaling in breast cancerSemantic proximity Read ↗

ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.