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Article

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

The Journal of biological chemistry - 16 Feb 2018

Cribbs Adam, Hookway Edward S, Wells Graham, Lindow Morten, Obad Susanna, Oerum Henrik, Prinjha Rab K, Athanasou Nick, Sowman Aneka, Philpott Martin, Penn Henry, Soderstrom Kalle, Feldmann Marc, Oppermann Udo

Abstract excerpt

Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of the innate and adaptive immune systems. Some studies have reported that NK cell activation and cytokine secretion are controlled epigenetically but have yielded only...

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Identifiers

PMID: 29301935
DOI: 10.1074/jbc.RA117.000698
PMCID: PMC5818173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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