Article

Oncogenic ERK signaling represses chaperone-mediated autophagy through transcriptional control of LAMP-2A

2026-03-04

Abstract excerpt

Chaperone-mediated autophagy (CMA) is a selective lysosomal degradation pathway governed by the rate-limiting receptor LAMP-2A and increasingly implicated in cancer. However, the oncogenic circuits that enforce CMA repression and whether this state is therapeutically reversible remain unclear. Here, we developed a quantitative bioluminescence-based reporter to measure CMA activity in human cancer cells and combine...

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Literature Corpus work: 1ae28b88-b49d-5be2-842b-813e6bc305c7
DOI: 10.64898/2026.03.03.709259

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