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Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors

7 Mar 2025

Abstract excerpt

Tumors often recapitulate programs to acquire invasive and dissemination abilities, during which pro-metastatic proteins are distinctively stabilized in cancer cells to drive further progression. Whether failed protein degradation affects the metastatic programs of cancer remains unknown. Here, we show that the human cancer cell-specific knockout (KO) of LAMP-2A, a limiting protein for chaperone-mediated...

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PMID: 40055574
DOI: 10.1038/s44321-025-00210-w

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