Article

Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8 <sup>+</sup> T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis

2022-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Autoimmune toxicity occurs in up to 60% of patients treated with immune checkpoint inhibitor (ICI) cancer therapy and is an increasing clinical challenge with the expanding use of these treatments. To date, human immunopathogenic studies of immune related adverse events (IRAEs) have relied upon sampling of circulating peripheral blood cells rather than affected tissues. Here, we directly obtaine...

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Literature Corpus work: 599343e0-74e4-53ff-a700-3460444e7893
DOI: 10.1101/2022.12.18.517398

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