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Autoreactivity of Peripheral Helper T Cells in the Joints of Rheumatoid Arthritis

12 Apr 2021

Abstract excerpt

Abstract Autoreactive CD4 T cells are thought to play pivotal roles in the pathogenesis of rheumatoid arthritis (RA). Recently, a subset of CD4 T cells that express high levels of programmed death-1 (PD-1) but are distinct from follicular helper T cells have been identified in the joints of RA patients and named peripheral helper T (Tph) cells. Because PD-1 is expressed on T cells chronically stimulated with the...

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PMID: 33846228
DOI: 10.4049/jimmunol.2000783

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