Article

Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney

2025-10-09

Abstract excerpt

<h4>Summary</h4> Patients with chronic kidney disease (CKD) face elevated fracture incidences, but mechanisms underlying CKD-related bone loss remain unclear. Using the adenine-induced chronic kidney injury (AdKI) murine model, we identified that AdKI induces dysregulated glucose metabolism in bones and kidneys via in vivo and ex vivo metabolic tracing. Ex vivo 13 C-metabolic tracing of osteocyte-enriched femo...

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Literature Corpus work: 82ee7b6e-c1f9-504e-a7c3-033eee048bfc
DOI: 10.1101/2025.10.08.681058

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