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Article

Exploiting the mediating role of the metabolome to unravel transcript-to-phenotype associations.

eLife - 9 Mar 2023

Auwerx Chiara, Sadler Marie C, Woh Tristan, Reymond Alexandre, Kutalik Zoltán, Porcu Eleonora

Abstract excerpt

Despite the success of genome-wide association studies (GWASs) in identifying genetic variants associated with complex traits, understanding the mechanisms behind these statistical associations remains challenging. Several methods that integrate methylation, gene expression, and protein quantitative trait loci (QTLs) with GWAS data to determine their causal role in the path from genotype to phenotype have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36891970
DOI: 10.7554/eLife.81097
PMCID: PMC9998083

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