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Causality of Genetically Determined Metabolites on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study In Silico.

Metabolic syndrome and related disorders - 1 Sept 2024

Zhang Zekai, Cao Beibei, Wu Qiutong

Abstract excerpt

Introduction: Chronic kidney disease (CKD) is associated with metabolic disorders. However, the evidence for the causality of circulating metabolites to promote or prevent CKD is still lacking. Methods: The two-sample Mendelian randomization (MR) analysis was conducted to evaluate the latent causal relationship between the genetically proxied 486 blood metabolites and CKD. Genome-wide association study (GWAS)...

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PMID: 38742978
DOI: 10.1089/met.2024.0030

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