Article

STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells

2022-07-20

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint molecule programmed death-ligand 1 (PD-L1) is overexpressed in cancer cells and imparts resistance to cancer therapy. Although membrane PD-L1 has been targeted for cancer immune therapy, nuclear PD-L1 was reported to confer cancer resistance. Therefore, it is important to regulate the nuclear PD-L1. The mechanisms underlying the therapeutic efficacy of PD-L1 targeting...

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Literature Corpus work: 1acf3776-cadc-5a69-bcef-18f8ef41ffcd
DOI: 10.21203/rs.3.rs-1813656/v1

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