Article

Sub-lethal doses of chemotherapeutic agents induce senescence in T cells and upregulation of PD-1 expression

2022-09-22

Abstract excerpt

Cellular senescence refers to a pause in the cell cycle, usually in response to internal and/or external stress, including telomere dysfunction, abnormal cellular growth, and DNA damage. Several chemotherapeutic drugs, such as melphalan (MEL) and doxorubicin (DXR), induce cellular senescence in cancer cells. However, it is not clear whether these drugs induce senescence in immune cells. We evaluated the induction...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 353d726a-1b96-51c2-ab2b-639933e5d85c
DOI: 10.21203/rs.3.rs-2058604/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sub-lethal doses of chemotherapeutic agents induce senescence in T cells and upregulation of PD-1 expressionDOI 10.21203/rs.3.rs-2058604/v1Read

Therapy-Induced Senescence: Novel Approaches for Markers IdentificationSemantic proximity Read

Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer.Semantic proximity Read

Role of senescence induction in cancer treatmentSemantic proximity Read

Characteristics and mechanisms of T‐cell senescence: A potential target for cancer immunotherapySemantic proximity Read

Therapy-Induced Senescence in CancerSemantic proximity Read

Senescence and the tumor-immune landscape: Implications for cancer immunotherapy.Semantic proximity Read

STING mediates nuclear PD-L1 targeting-induced senescence in cancer cellsSemantic proximity Read

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectivesSemantic proximity Read

Senescence in polyploid giant cancer cells: A road that leads to chemoresistance.Semantic proximity Read

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 CellsSemantic proximity Read

Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospectsSemantic proximity Read

Advances in melanoma senescence and potential clinical application.Semantic proximity Read